SCIENCE SUPPORTING ORAL HYALURONIC ACID
Hyaluronic Acid – General
◊ Increasing chondrocyte density – Guidolin et al
◊ Promoting synovium metabolism – Maniwa et al
◊ Normalizing synovial fluid – Asari et al
◊ Treating sharp pain – Day et al
Therefore, there is extensive scientific support confirming HA has a strong relationship with knee joint health.
Oral Absorption Of Hyaluronic Acid
◊ 13.3% of the oral dose was absorbed and taken up in joints and connective tissue
◊ Scintigraphy scan of the dog chest showing distribution of hyaluronic acid in the joints, bones and salivary glands two hours after administration
◊ Scintigraphic scan of rat chest showing distribution in joints, bones, muscles and salivary glands 4 hours after administration
Mechanism Of Oral Hyaluronic Acid Treatment for Knee Pain
◊ Enhancing the production of the IL-10 an anti-inflammatory cytokine
◊ Up regulates suppressor of SOCS3 cytokine expression and down regulates an inflammatory cytokine pleiotrophin
◊ Inflammatory cytokine levels were significantly increased in the placebo group (p<0.05) and significantly reduced in the HA group (P<0.05)
◊ Bradykinin, which relates to inflammation and pain, and leptin, which is related to osteoarthritis caused by obesity, the levels of both substances were significantly lower in the HA group than the placebo group (P<0.05)
Use Of Oral Hyaluronic Acid In Horses
10 horses divided into 3 groups- Oral group received 100 mg of HA daily for 7 days
◊ Baseline blood samples taken at the beginning of the study
◊ Daily blood samples taken for 7 days
◦ Oral group
- Oral HA group had the highest level of serum HA
- Oral HA group was the only group to have a substantial increase in serum HA on day 7
◦ Intravenous group
- had a slight elevation in HA on day 4
◦ Control group
- had constant levels for 7 days
◊ 48 yearlings divided into 2 groups, 100 mg of HA daily and control
◊ HA significantly reduced joint swelling compared to no treatment
◊ 100 mg of hyaluronic acid administered orally daily
◊ There was a reduced number of times veterinarians were asked to examine racing thoroughbreds for lameness
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